Zocol Capsule Side Effects

Fluconazole is generally well tolerated. The commonest side effects associated with fluconazole are symptoms associated with the gastrointestinal tract. These include nausea, abdominal discomfort, diarrhoea and flatulence. After gastrointestinal symptoms, the second most commonly observed side effect was rash. Headache has been associated with fluconazole. In some patients, particularly those with serious underlying diseases, e.g. AIDS and cancer, changes in renal and hematological function test results and hepatic abnormalities have been observed during treatment with fluconazole and comparative agents, but the clinical significance and relationship to treatment is uncertain. Exfoliative skin disorders, seizures, leukopenia including neutropenia and agranulocytosis, thrombocytopenia, and alopecia have occurred under conditions where a causal association is uncertain. If a rash, which is considered attributable to fluconazole develops in a patient treated for a superficial fungal infection, further therapy with this agent should be discontinued. If patients with invasive/systemic fungal infections develop rashes, they should be monitored closely and fluconazole discontinued if bullous lesions or erythema multiforme develop.
In rare cases, as with other azoles, anaphylaxis has been reported.